BioRed® for Eye health
Phosphatidylcholine and Lysophosphatidylcholine (LPC) was recently proven to be a major transporter of DHA to the brain and retina. BioRed® contains 90-96% of Phosphatidylcholine and LPC bound to EPA & DHA therefore increasing the absorption into the brain and eyes.
Dry Eye Disease
Is a highly prevalent, multifactorial disease often presented with burning, foreign body sensation and pain due to inflammation.
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OTC eye drops alone may not provide sufficient relief and need to seek out additional treatments. One probable root cause of DED is the Meibomian gland dysfunction that produces an oil found in healthy tears.
Dry Eye disease (DED)
Meibomian gland dysfunction (MGD) affects the secretion of oily meibum: a complex mixture of lipids, fatty acids, cholesterol, phospholipids, etc. which forms the tear film’s outer layer - the lipid layer. The meibum aids in reducing the evaporation of tears and gives it better optical durability 3.
Changes in either one the layers of tear film (mucin, aqueous and lipid layer) affects each other and its ability to protect and nourish the surrounding tissue properly, resulting in inflammation of the eye surface 3.
Reducing Inflammation
Inflammation is central to the development of dry eye disease and krill oil has been shown to have better bioavailability, anti-inflammatory, pro-resolving and also antioxidant abilities than other omega-3 sources. According to the American Academy of Ophthalmology in 2017, krill oil is effective as an anti-inflammatory intervention for DED, improving signs & symptoms & may also slow down disease progression.
Choline For Dry Eye And Eye Surface
Latest research shows that choline is important in eye health and disease. Choline is an essential component of acetyl choline as well as membrane phospholipids, and plays a critical role in vision 2. Choline is important for anti-nociception in the central nervous system and involved in the production and secretion of tears contributing to stability of the cells and tears on the eye surface including retinal cell development and differentiation 8.
Tear Film Stability And Eye Surface
Tear film Instability is a key cause for DED and is an important treatment strategy for managing DED. Krill oil was able to significantly improve Tear Breakup Time (TBUT) (p<0.05) compared to placebo in 60 and 90 days. Krill oil was also able to significantly improve Ocular Surface Disease Index (OSDI) (p<0.05) at 60 days but not fish oil.
“Only Krill oil was able to reduce basal tear level of proinflammatory cytokine interleukin 17A compared to placebo and fish oil.”
Krill Oil For Dry Eye Better Bioavailability
It was recently discovered a particular receptor Mfsd2a that facilitates uptake of Phospholipids bound to Omega-3 into the brain and eyes but not fish oil which is in TAG form5. In a recent study, the PC/LPC bound Omega-3 in Krill oil was able to increase efficiently retinal DHA but not fish oil 7.
Choline deficiency may enhance inflammation and delay wound healing on the eye surface contributing to the development of eye symptoms associated with dry eye disease 8.”
Choline: an essential nutrient
Role of choline in ocular disease:
Deficiency in choline is is associated with retinal hemorrhage, glaucoma, and dry eye syndrome.
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​Choline helps in various eye diseases by reducing inflammation and oxidation.
“Choline is important for anti-nociception in the central nervous system and involved in the production and secretion of tears contributing to stability of the cells and tears on the eye surface including retinal cell development..”
BioRed: Astaxanthin – fat soluble antioxidant
Studies have shown Astaxanthin 4-12mg/day for 28d showed improved visual acuity (5m) vs. baseline for healthy individuals.
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​Astaxanthin is a fat soluble carotenoid that is poorly absorbed, but its bioavailability is improved due to the higher content of phosphatidylcholine.
REFERENCES:
1. Deinema LA, Vingrys AJ, Wong CY, Jackson DC, Chinnery HR, Downie LE. A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease. Ophthalmology. 2017 Jan;124(1):43-52
2. Faiq, M.A.; Wollstein, G.; Schuman, J.S.; Chan, K.C. Cholinergic nervous system and glaucoma: From basic science to clinical applications. Prog. Retin. Eye Res. 2019, 72, 100767.
3. https://www.reviewofoptometry.com/article/im- prove-your-understanding-of-meibomian-gland-function-and-dysfunction
4. Miki, W. Biological functions and activities of animal carotenoids. Pure Appl. Chem. 1991, 63, 141-146.
5. Wong BH, et al. Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14.
6. Burri, L., et al. (2012). Int. J. Mol. Sci. 13, 15401–15419
7. Sugasini D. et al (2020) Nutrients 2020, 12, 3114.
8. Hwang JS, Shin YJ. Role of Choline in Ocular Diseases. Int J Mol Sci. 2021;22(9):4733. Published 2021 Apr 29.
9. http://www.aao.org/eye-health/tips-pre- vention/fix-dry-eye-treatment-eyedrops